Plasma-enhanced functionalization of inorganic oxide substrates

U.S. Patent # 7723126 (2010)
Inventors: F.S. Denes, S.O. Manolache, J.M. Helgren, B.J. Larson, and M.G. Lagally.

Methods for producing plasma-treated, functionalized inorganic oxide surfaces are provided. The methods include the steps of subjecting an oxide surface to a plasma to create hydroxyl functionalities on the surface and reacting the hydroxyl functionalities with epoxy group-containing molecules in situ in the absence of plasma. Biomolecules may be immobilized on the resulting functionalized surfaces. The methods may be used to treat a variety of oxide surfaces, including glass, quartz, silica and metal oxides.